Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist. It mimics the GLP-1 hormone that the digestive tract naturally releases when you eat. This hormone helps increase insulin production, which lowers blood sugar levels. In addition, high levels of GLP-1 reduce appetite and promote feelings of fullness. As a result, semaglutide can help decrease hunger, reduce food cravings, improve eating control, and lower preference for high-fat foods.