Like many prescription medications, Tirzepatide may cause side effects as your body adjusts. The most commonly reported include nausea, diarrhea, constipation, abdominal discomfort, fatigue, and decreased appetite. Some individuals may also experience mild injection site reactions such as redness, swelling, or tenderness.

Less common but more serious side effects may include pancreatitis, thyroid tumors, or severe allergic reactions. It’s important to speak with your healthcare provider if you experience any side effects or have concerns during treatment.